Hyperpigmentation: Melasma, Sun Spots and Post-Inflammatory Marks

TL;DR

Hyperpigmentation means that an area of skin contains more pigment than the surrounding skin, but it is not one diagnosis. Melasma usually appears as broader, often symmetrical facial patches that recur or darken with light and hormonal change. UV-related pigmentation includes freckles, mottled tone and more defined sun spots that build gradually. Post-inflammatory hyperpigmentation, or PIH, appears after acne, eczema, irritation, injury or a procedure.

The broad treatment principles overlap: prevent new pigment with consistent broad-spectrum sunscreen, reduce pigment production with a targeted treatment, and consider a retinoid where suitable to improve cell turnover and pigment distribution. The details matter. Melasma often benefits from tinted visible-light protection, PIH will not settle well if the underlying inflammation continues, and a new or changing pigmented lesion should be assessed rather than treated with skincare.

Hyperpigmentation in one view

  • Identify the pattern before choosing products.
  • Use broad-spectrum sunscreen every morning; for melasma, a suitable tint can add visible-light protection.
  • Use one targeted pigment product rather than several “brightening” serums.
  • Add a retinoid only if it is suitable and your skin barrier is settled.
  • Avoid irritation: inflammation can create or prolong PIH.
  • Expect gradual change over several months, with maintenance often needed for melasma.

What type of hyperpigmentation do you have?

Melasma

Melasma usually appears as flat brown or grey-brown patches on the cheeks, forehead, upper lip or jawline. It is often fairly symmetrical and may become more noticeable after sun exposure, during pregnancy or alongside other hormonal changes.

It behaves more like a long-term tendency than a mark that can simply be removed once. Treatment can improve it, but relapse is common, so maintenance and light protection matter.

UV-related pigmentation

Cumulative ultraviolet exposure can cause a mottled tone, freckles and defined brown marks often called sun spots or solar lentigines. They tend to appear on exposed areas such as the face and backs of the hands.

Skincare can improve general uneven tone and help prevent new marks. A single well-defined sun spot may respond better to clinician-led treatment, and any mark that is new, changing, irregular, bleeding or symptomatic should be medically assessed.

Post-inflammatory hyperpigmentation

PIH is the brown, grey-brown or red-brown colour that remains after inflammation. Acne is a common cause, but it can also follow eczema, picking, burns, irritation or a procedure.

It is often more persistent in deeper skin tones. The first step is to control whatever is creating new inflammation. An aggressive “brightening” routine that repeatedly irritates the skin can make PIH last longer.

Step 1: Prevent new pigment with daily photoprotection

Pigmentation treatment is difficult if light exposure continues to stimulate new pigment. Use a broad-spectrum sunscreen as the final step of your morning routine and apply enough to form an even layer.

For melasma, UVA and UVB protection may not be the whole story. Visible light can also worsen pigmentation, particularly in skin with more melanin. In a randomised trial, an SPF 50 sunscreen containing iron oxides for visible-light protection improved melasma outcomes more than a similar UV-only sunscreen when both were used alongside hydroquinone [1]. Another trial found better prevention of melasma relapse when protection extended into shorter wavelengths of visible light [2].

This does not mean everyone with pigmentation needs tint. The colour has to suit your skin well enough for you to apply it generously. For PIH or UV-related pigmentation, the most useful starting point may simply be a broad-spectrum sunscreen you will use consistently.

A tinted sunscreen for melasma and recurring pigmentation

Mesoestetic Mesoprotech Melan 130 Pigment Control on a warm cream studio background

Doctor-selected • Pigment-focused SPF

mesoestetic® mesoprotech® melan 130 pigment control

£59.95 Available
Why I chose it

I chose mesoestetic® mesoprotech® melan 130 pigment control because it combines very high broad-spectrum protection with a tint designed to extend protection into visible light. It is a hybrid-filter sunscreen rather than a purely mineral product, and it also contains Azeloglycine to support pigment control.

Best for

You have melasma or recurring facial pigmentation and the tint works with your skin tone.

Usual place

Use it as the final morning skincare step.

How to introduce it

Apply a generous, even layer every morning and reapply during prolonged exposure, after swimming, sweating or towel drying.

Another option may be better if

Choose another sunscreen if the tint looks unnatural, gathers in facial hair or makes you use less than you should.

Step 2: Reduce pigment production with a targeted treatment

Melanin is made through a sequence of reactions. Tyrosinase is one of the key enzymes in that pathway, so many pigmentation treatments are designed to reduce its activity.

Examples include prescription hydroquinone and cosmetic ingredients such as kojic acid and azelaic acid. They do not all work equally, and the complete formula matters. A split-face study found that adding kojic acid to a hydroquinone and glycolic acid gel improved melasma outcomes compared with the same formula without kojic acid [3].

Other ingredients act through different pathways. Tranexamic acid may reduce signals that stimulate melanocytes, while niacinamide can reduce pigment transfer into surrounding skin cells. A randomised study found improvement with topical tranexamic acid formulations, although the evidence remains more product-specific than it is for prescription hydroquinone [4].

You usually need one well-chosen targeted product, not several pigment inhibitors at once. More layers can mean more irritation without a better result.

A multi-pathway pigment serum

Mesoestetic Melan Tran3x Concentrate on a warm cream studio background

Doctor-selected • Targeted pigment care

mesoestetic® melan tran3x concentrate

£108.45 Available
Why I chose it

I chose mesoestetic® melan tran3x concentrate because it combines several complementary ingredients. Kojic acid provides the tyrosinase-inhibiting element, while tranexamic acid, niacinamide and exfoliating ingredients support other parts of the pigmentation pathway.

Best for

You have broader or recurring patches of uneven pigmentation and your skin already tolerates active products.

Usual place

Use it after cleansing and before moisturiser.

How to introduce it

Start once daily and introduce it as the only new targeted pigmentation product so you can judge tolerance.

Another option may be better if

Choose a simpler formula if your skin is reactive or your barrier is unsettled. If the pattern is broad, symmetrical, recurrent or difficult to identify, arrange a consultation rather than intensifying the routine yourself.

Step 3: Consider a retinoid to support turnover and pigment distribution

Retinoids can support pigmentation treatment by changing how epidermal cells mature and how pigment is distributed through the upper skin. Controlled trials have shown that topical tretinoin can improve hyperpigmented lesions associated with photoageing [5], PIH in Black patients [6] and melasma [7].

That does not mean everyone needs prescription tretinoin. A cosmetic retinoid may be more practical, especially if you also want to improve fine lines or texture. The benefit develops gradually, and irritation matters: redness and peeling can create more inflammation and may worsen PIH.

Chemical exfoliants such as glycolic acid can also help remove pigmented surface cells and improve texture. The aim is controlled, sustainable turnover rather than visible peeling.

A retinoid with glycolic acid

SkinBetter Science AlphaRet Overnight Cream on a warm cream background

Doctor-selected • Treat

SkinBetter Science AlphaRet Overnight Cream

£142.00 Available
Why I chose it

I chose SkinBetter Science AlphaRet Overnight Cream because it combines AlphaRet retinoid technology with glycolic acid. This can be useful when uneven tone sits alongside fine lines or rough texture. A small product-specific randomised study reported improvements in dyschromia and other signs of photodamage, with less irritation than the comparison retinol and tretinoin products [8].

Best for

You want a consultation-guided evening treatment and your skin is reasonably accustomed to active products.

Usual place

Use it after cleansing and before moisturiser if needed.

How to introduce it

Follow the agreed introduction schedule and do not add another retinoid or a separate exfoliating acid at the same time.

Another option may be better if

Choose another route if your skin is irritated, you are very prone to PIH after inflammation, you already use a retinoid, or you are pregnant, planning pregnancy or breastfeeding [9].

How the approach changes by pigment type

For melasma

Think in terms of control and maintenance rather than a one-off cure. Start with consistent broad-spectrum sunscreen, and consider a tint with iron oxides if it suits you. Add one targeted pigment product and, where appropriate, a retinoid. Melasma often needs a personalised plan because hormonal factors, visible light, skin sensitivity and the depth of pigment can change the response.

For UV-related pigmentation

Daily sunscreen helps prevent new marks and stops existing pigmentation being continually stimulated. A retinoid and antioxidant or pigment-targeting product can improve general mottled tone over time. Individual sun spots may need assessment and a procedure if you want a more complete result.

For PIH

Treat the cause first. If acne is still active, preventing new breakouts is usually more important than adding another brightening serum. Keep cleansing and moisturising gentle, use sunscreen and add one targeted product. A retinoid may help, but introduce it cautiously.

How to build the routine without overdoing it

Introduce one treatment layer at a time so you can identify what helps and what irritates.

  1. Weeks 1–2 Establish a gentle cleanser, moisturiser if needed and daily broad-spectrum sunscreen. If melasma is your main concern, decide whether a tinted visible-light-protective formula works for you.
  2. Weeks 3–6 Add one targeted pigment serum once daily. Do not introduce a retinoid, exfoliating acid and several brightening serums in the same week.
  3. From week 6 onwards If the routine is well tolerated and a retinoid is suitable, introduce it gradually in the evening. Use fewer days or separate it from the targeted product if the combination becomes irritating.
  4. Review at 8–12 weeks Look for early changes in evenness and whether fewer new marks are appearing. Established pigmentation often needs several months. If the skin is becoming inflamed, simplify rather than intensify.

When to seek individual advice

Arrange an assessment if the pigmentation is broad, symmetrical or recurrent and you are unsure whether it is melasma; if it has not improved after several months; if it appeared after a procedure; or if sensitive skin makes active products difficult to use.

A new, changing, irregular, raised, bleeding or symptomatic pigmented lesion should be assessed by your GP or a dermatology service rather than treated with cosmetic skincare.

Dr Max Greenfield, MBBS, BSc, MRCS(Eng)

Founder, The Curatory

References and further reading

  1. Castanedo-Cazares JP, Hernandez-Blanco D, Carlos-Ortega B, Fuentes-Ahumada C, Torres-Alvarez B. Near-visible light and UV photoprotection in the treatment of melasma: a double-blind randomized trial. Photodermatology, Photoimmunology & Photomedicine. 2014;30(1):35–42. (opens in a new tab)
  2. Boukari F, Jourdan E, Fontas E, et al. Prevention of melasma relapses with sunscreen combining protection against UV and short wavelengths of visible light: a prospective randomized comparative trial. Journal of the American Academy of Dermatology. 2015;72(1):189–190.e1. (opens in a new tab)
  3. Lim JTE. Treatment of melasma using kojic acid in a gel containing hydroquinone and glycolic acid. Dermatologic Surgery. 1999;25(4):282–284. (opens in a new tab)
  4. Xing X, Chen L, Xu Z, Jin S, Zhang C, Xiang L. The efficacy and safety of topical tranexamic acid versus conventional hydroquinone in the treatment of melasma. Journal of Cosmetic Dermatology. 2020;19(12):3238–3244. (opens in a new tab)
  5. Griffiths CEM, Goldfarb MT, Finkel LJ, et al. Topical tretinoin treatment of hyperpigmented lesions associated with photoaging in Chinese and Japanese patients: a vehicle-controlled trial. Journal of the American Academy of Dermatology. 1994;30(1):76–84. (opens in a new tab)
  6. Bulengo-Ransby SM, Griffiths CEM, Kimbrough-Green CK, et al. Topical tretinoin therapy for hyperpigmented lesions caused by inflammation of the skin in Black patients. New England Journal of Medicine. 1993;328(20):1438–1443. (opens in a new tab)
  7. Kimbrough-Green CK, Griffiths CEM, Finkel LJ, et al. Topical retinoic acid for melasma in Black patients: a vehicle-controlled clinical trial. Archives of Dermatology. 1994;130(6):727–733. (opens in a new tab)
  8. McDaniel DH, Mazur C, Wortzman MS, Nelson DB. Efficacy and tolerability of a double-conjugated retinoid cream versus 1.0% retinol cream or 0.025% tretinoin cream in subjects with mild to severe photoaging. Journal of Cosmetic Dermatology. 2017;16(4):542–548. (opens in a new tab)
  9. Medicines and Healthcare products Regulatory Agency. Oral retinoid medicines: revised and simplified pregnancy prevention educational materials for healthcare professionals and women. Includes UK precautionary advice on topical retinoids in pregnancy. (opens in a new tab)

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